Magnitude of lipoprotein (a) in diabetes mellitus.

One hundred and three patients, 76 with diabetes mellitus alone (48- Non-Insulin dependent diabetes and 28 Insulin dependent diabetes) and 27 diabetics having coronary heart disease (CHD) and 27 normal control subjects were included in this study. All the 27 diabetics with CHD were Non-Insulin dependent. The patients and the controls were investigated for serum Lp (a), triglycerides, cholesterol, VLDL-C, LDL-C, HDL-C, apo A1 and apo B. The objective was to assess and compare the level of lipoproteins, especially the lipoprotein (a), in diabetic and non-diabetic subjects and to compare the level of the aforementioned parameters in diabetics with and without CHD. The Lp (a) and other lipid parameters were significantly raised (P < 0.001) except HDL-C and apo A1 that were significantly decreased (P < 0.001) both in diabetic patients with and without CHD, as compared to the control group. The diabetics with CHD showed significantly elevated (P < 0.001) Lp (a) and lipid profile, and significantly low (P < 0.001) HDL-C and apo A1 levels as compared to the patients having diabetes alone. No significant difference was observed in the levels of the above parameters when NIDDM patients were compared with IDDM group. In both NIDDM and IDDM patients significantly low (P < 0.001) HDL-C level and significantly high (P < 0.001) Lp (a) level along with the aforementioned lipid parameters was observed as compared to control group. Elevated levels of Lp (a) and lipid profile in diabetic subjects suggest their involvement in atherogenesis and subsequent development of CHD.